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These results indicate that B12 deficiency affects the levels of the cytokines in AT and circulation, thus inducing pro-inflammatory factors which could contribute to adipose dysfunction

Sci Transl Med 11(478):eaau5266 Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K et al (2010) The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Cancer 7 , 763777 (2007)

doi: 10.1007/s40263-021-00888-9

There is a large gap waiting to be filled by subsequent researchers to yield better therapeutic targets and methods to cure breast cancer, and the role of GPxs in breast cancer should be studied as an extremely important issue