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Excessive androgens, on the one hand, induce disorders of lipid metabolism by promoting visceral fat deposition, enlarging adipocytes, enhancing inflammatory response, macrophage infiltration, and apoptosis in women ( In summary, evidence from pre-clinical and clinical studies reveal the consistent regulatory roles of androgens/AR in glucose and lipid metabolism, with clear sex-dependent differences ( Figure 1 )

Our results revealed that treated patients showed elevated levels of neurodegeneration biomarkers (BDNF and PDGF-BB), while levels of TBARS and isoprostanes, indicators of lipid oxidative damage, were significantly decreased compared to diagnostic group

In 1967, the compression ring at the Forum was one of the largest of its kind in the country

Leonard et al

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