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Studies have also proposed a role in ryanodine receptor modulation, interleukin-1 (IL-1) secretion and endoplasmic reticulum stress-mediated autophagy 7,12,13,14,15

These findings support the potential for UA delivery to colon tissues to achieve its anti-CRC activity

Celiac disease is frequently associated with various autoimmune and idiopathic conditions, such as autoimmune thyroid disorders (AITDs) (14)

(Source 1) Suboptimal and deficient glutathione levels are associated with aging and an increased risk for chronic diseases, including: Mitochondrial dysfunction Neurodegenerative disease, including Alzheimers and Parkinsons disease Cancer Chronic liver disease Metabolic disease, including diabetes and hypertension Cardiovascular disease Pulmonary Infertility Autoimmune diseases, including lupus and multiple sclerosis Mental health disorders Cystic fibrosis (Source 1, 2) A viral illness, including SARS-CoV-2, the virus that causes Covid-19, can also cause glutathione deficiency

The effects of Waon therapy became stable after 10 treatments and persisted throughout the observation period of a mean duration of 14 months [75]