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Also discard it if the vial was left unrefrigerated after mixing, froze accidentally, or was handled with questionable sterile technique

FR dynamically cycles between the cell surface and intracellular compartments, facilitating the efficient internalization of drugs bound to the receptor [117]

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Excess HOCl was removed, and buffer exchange was performed using NAP-5 columns

Collectively, advancing the field will require harmonized methodologies, multi-dimensional mechanistic analyses, and clinically relevant outcomes that reflect the complex physiological demands of aging