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36 Type 2 diabetes
240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

This allows for targeted dosing and personalization that generic products cant offer

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Lower binding energy between the macromolecular protein and small molecule ligand indicates a higher binding probability and stability
