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An ex-vivo (made on human skin but not on real people) study examined the cocoa polyphenols and found that 0.5-0.75% of them improved skin tone and elasticity and had a similarly positive impact on GAGs (important natural moisturizing factors in the skin) and collagen synthesis than a commercial high-end moisturizer (it was an Estee Lauder one)

A meta-analysis provided robust evidence that periodontitis is linked to systemic inflammation as measured by serum CRP levels, and higher hsCRP titers were consistently associated with chronic and aggressive stages of the condition

In the absence of significant heterogeneity, a fixed-effects model was used for the pooled analyses while a random-effects model was used if there was significant heterogeneity present

doi: 10.1186/s12931-022-02309-x

However, maintaining a nutritious diet can synergize with the treatment