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Punctal plugs, which use small collagen or silicone plugs to temporarily block the tear ducts, are effective in patients with severe ADDE, blocking tear drainage and increasing tear retention on the ocular surface [20]
In addition to NMDA antagonism, however, KET has a myriad of effects on neurotransmitters which include the following: increase of synaptic concentrations of acetylcholine in the spinal cortex, hippocampus, and neocortices
