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FIGURE 2 Mechanical stress induced by increased IOP in glaucoma results in increased EGF receptor expression following astrocyte activation, as well as increased levels of TNF-, matrix metalloproteinases (MMPs), endothelins, and nitric oxide synthase 2 (NOS-2), ultimately leading to a neurodegenerative response (Liddelow et al., 2017

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1998 Feb;83(2):362-9

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For people with rapidly growing tumors: Methotrexate can cause tumor lysis syndrome

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Valvular Heart Disease and Pulmonary Arterial Hypertension)

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