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Result and Conclusion Repurposing of drugs is economical compared to that of traditional treatment methods and it can be delivered to a wider range of people in need

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MD simulations also identified a natural compound schisandrin B (Sch B) that specifically bound to the ligand-binding domain of PXR, induced conformational changes and disrupted the PARP1PXR interaction interface, thus suppressed the ribosylation

Acetyl L-Carnitine (ALCAR) is an acetylated form of L-Carnitine which is similar to typical L-Carnitine but is able to cross the blood-brain barrier