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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)

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However, despite low vitamin D levels in asthma patients, hypovitaminosis D has not been linked with a higher risk or increased severity of asthma (228)