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High-dose vitamin K is an effective antidote for warfarin poisoning 30,31 because sufficient input of vitamin K can provide VKH 2 for GGCX through the alternative vitamin K reduction pathway, bypassing dysfunctional VKOR by the unidentified antidotal enzyme 32 (Extended Data Fig

However, the rational design and synthesis of new MGDs is still little studied

10.1172/JCI117480 [DOI] [PMC free article] [PubMed] [Google Scholar] 220.Ignarro LJ, Napoli C, Loscalzo J

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