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Similar to arrestin-mediated endosomal signaling, G protein-mediated endosomal signaling has distinct effects from G protein signaling at the plasma membrane, with 2 AR G protein endosomal signaling resulting in changes in transcriptional regulation [106]

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The Critical Problem: No Human Clinical Evidence As of early 2026, not a single randomized controlled trial (RCT) has been completed and published for human musculoskeletal indications

Chen Y, Chai Y, Yin B, Zhang X, Han X, Cai L, Yin N, Li F

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