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Glutathione Peroxidase (Gpx) Gpx is a tetrameric selenoprotein that catalyzes the detoxification of H 2 O 2 (reaction 6) and lipid peroxides (reaction 7) by reducing glutathione (GSH), mainly in the mitochondria but also in the cytosol, playing a key role in the protection of cells from oxidative damage by inhibiting lipid oxidation

Functional complementation of the H 2 O 2 -sensitive yeast growth by transforming GhGPXs in gpx3 mutant yeasts The GPX homolog YIR037W / HYR1 / GPX3 was found in the Saccharomyces Genome Database, and a previous study indicated that gpx3 mutant was hypersensitive to peroxides, and with decreased ~57% GPX activity in gpx3 mutants with respect to wild type (BY4741) 47

10.1208/s12249-022-02297-7 74 KangE

Hayllar, J

This suggests that TCM can be used to intervene in AMD by adjusting the intestinal flora, increasing SCFAs and BAs, and ameliorating oxidative damage, apoptosis, inflammation, and altered choroidal hemodynamics