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Nevertheless, currently available DNMT inhibitors are not sufficiently selective, leading to off-target adverse effects including global DNA hypomethylation, oncogene activation and increased genomic instability

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Therefore, silibinin offers significant promise as a therapeutic agent in reversing tumor drug resistance through various mechanisms, including inhibition of drug efflux pumps, modulation of cell adhesion, and regulation of key signaling pathways like STAT3

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Jacquesson-Fournols L., Alvarez S., Cohen M., Clement P., Menezo Y.J

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