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The brains restricted antioxidant capacity, high energy demand, high levels of transition metals, such as iron and copper, and a high concentration of polyunsaturated fatty acids which can be subjected to lipid peroxidation [103105] make the nervous system particularly vulnerable to oxidative stress [106]

Metal ions, being toxic to the nervous system and causing oxidative stress, have been reported to participate in the pathogenesis of AD [123]

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Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Womens Heart and Health Study and Meta-Analysis

For patients with both MCAS and autoimmunity, flare-ups are often more severe, prolonged, and resistant to standard interventions