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The above results show that GPX4 is upregulated by anticancer therapies in vivo, and GPX4 inhibitors in combination with cisplatin reduced tumour size and increased survival in a mouse model of ovarian cancer

X-ray crystallography has confirmed that the critical arginine residue at position 154 (R154) in its coenzyme A-binding pocket forms a hydrogen bond network with the 3-phosphate group of coenzyme A (Skiba et al., 2020)

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Specifically, melanoma persisters surviving BRAFi and MEKi have been shown to exhibit increased mesenchymal gene expression 12,41,42 , and to shift into a dedifferentiated state with high NGFR expression 34,43,44 (Fig