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Even a minor deficiency of B6 can lead to a significant reduction in neurotransmitter levels
Among its three isoforms (endothelial eNOS, neuronal nNOS, and inducible iNOS), nNOS-positive neurons predominantly regulate smooth muscle tone via the NO-cGMP pathway, mediating relaxation of the lower esophageal sphincter, pyloric sphincter, and Oddi sphincter, as well as coordinating gastrointestinal peristaltic rhythms ( + neurons and SIP syncytia, leading to rhythmic disturbances in the jejunum, ileum, and colon, which is closely linked to gut microbiota dysbiosis (Sanders and Ward, 2019
