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Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration

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Lewis Lisa BodeiLisa BodeiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United StatesMore by Lisa Bodei Naga Vara Kishore Pillarsetty * Naga Vara Kishore PillarsettyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United StatesDepartment of Radiology, Weill Cornell Medicine, New York, New York 10065, United States * Email: [email protected]More by Naga Vara Kishore Pillarsetty Abstract Disseminated melanoma, particularly of rare subtypes such as mucosal or uveal melanoma, is a difficult to treat, deadly disease characterized by poor median survival and resistance to a wide range of treatments

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