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In contrast, higher rates of early-onset PCO persist in patients implanted with silicone IOLs, with incidences ranging from 11% to 40.7% reported as early as 6 weeks to 3 months postoperatively ( Table 2 ) (107, 110, 126, 127), although advances in silicone IOL manufacturing have now led to the release of square-edged silicone IOLs with lower rates (90, 128)

290 A phase I/II trial is currently underway to evaluate the efficacy of JHU-083 in advanced solid tumors (NCT04471415) (Table 1)

That step is called reconstitution

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Additional factors contribute to the differences between men and women, such as the increased risk women face due to certain characteristics