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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Obeid et al., 2015)

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While these functional improvements occurred in animal models, they suggest possible benefits for mobility and quality of life that would need confirmation in human trials

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91 In rats which underwent large resection of the small bowel, BPC 157 leads to the balanced adaptation of all three intestinal wall layers, resulting in normal weigh achievement, and attenuation of the remote organs damages (i.e., liver and brain), unlike rapidly presented and progressed short-bowel syndrome

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However, the so-called heme-anemic proteins with an incomplete heme saturation naturally occur outside the circulatory system [150]

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