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As TNF alpha is tumor-promoting [96, 97], the estrogen-mediated repression of TNF alpha may support a stronger anti-tumor immune microenvironment in bladder tumors of patients with female gonads

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neoformans secretes extracellular urease to modulate phagosomal pH, which in turn promotes the conditions necessary for melanization, persistence in phagocytic cells, and eventual traversal of the blood-brain barrier 34

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