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Opioids such as tramadol and tapentadol are also classified as secondline agents due to risks of developing dependence, respiratory depression, and potential abuse [336, 373]

Vitamin C and Alpha Lipoic Acid further boost antioxidant activity, helping to protect skin from oxidative stress and premature aging

Rituximab treatment of myasthenia gravis: a systematic review

CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

A pivotal RCT in 116 cannabis-dependent adolescents found that NAC (1,200 mg twice daily) more than doubled the odds of a negative urine cannabinoid test compared to placebo (OR 2.4, 95% CI 1.1-5.2) (Gray et al., Am J Psychiatry, 2012) [76]