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Phase 1 study dosing: Doses tested: 100 mcg to 1000 mcg daily Route: subcutaneous injection Results: dose-proportional effects on fat loss Safety: all doses well tolerated Phase 2 study dosing: Doses tested: 300 mcg to 600 mcg daily Route: once- or twice-daily subcutaneous injection Duration: 12 weeks typical Results: significant fat loss at all doses, with 500600 mcg showing the best efficacy Research Dosage Guidelines Based on available clinical data, research protocols generally consider the following ranges

Daskalaki I, Tavernarakis N

Bedford, MA, USA)

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Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist