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Here, we summarize the current understanding of the regulation of cell death and prosurvival pathways in the pathogenesis of ALD in multiple scenarios

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Proteins in the extracellular space represent a large store of cysteine available for cells to use for proliferation and survival

To address this, we additionally deleted the gene coding for Ggt in these cells and analyzed reduction of Grx1-roGFP2 by exogenous GSH in the resulting gshA gsiC ggt triple deletion mutant

However, the high recurrence rate after discontinuation suggests that simply suppressing systemic hormone levels may be insufficient to dismantle the established self-sustaining pathological network within the local microenvironment of the fibroids