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This study sheds light on the critical role of the NRF2-GPX2-NOTCH3 axis in advancing HNSCC, suggesting that targeting the NRF2-GPX2-NOTCH3 axis might offer a novel strategy to enhance treatment efficacy in HNSCC

The skin is the largest organ of the human body, which consists of three layers: epidermis, dermis, and subcutaneous

However, this would represent an off-label, experimental approach that falls well outside current NICE guidance or standard NHS practice, and should only ever be considered within a formal clinical trial or with robust multidisciplinary oversight, documented informed consent, and a clear monitoring plan

A known effector of PI3K, ARAP3, a GAP for small GTPases like RhoA and Arf6 has been shown to be a negative regulator of IgG IC-activated ROS production (Gambardella et al., 2013)

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