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Results Senescence-associated markers were enhanced in keloid fibroblasts and lesions Analysis of the heterogeneity of keloid cells revealed 28 cellular clusters (027) using unsupervised clustering of 34,043 cells based on established lineage-specific marker genes (Supplementary Fig

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GH was demonstrated to have both direct and indirect effects on ovarian and testicular function, with direct effects mediated by the explicit GH-GHR interactions, while indirect effects likely to be mediated through the local production of secondary factors, particularly Insulin-like growth factor (IGF) (6), a protein that is typically produced by the liver in response to GH stimulation (1, 7, 8)