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Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters

Among the proteins with increased expression in ME/CFS were 3-hydroxybutyrate dehydrogenase type 1 (BDH1) and acetyl-CoA acetyltransferase 2 (ACAT2), both of which are integral to fatty acid metabolism and processing of ketone bodies

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Mol Psychiatry 28(11):45004511 Rothammer N et al (2022) G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis