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Rossignol and Frye recommended a screening algorithm of mitochondria function to evaluate the following parameters of blood collected before breakfast: lactate, pyruvate, coenzyme Q10, CK, AST, ALT, AST/ALT ratio, glucose, ammonia, concentration of amino acids, CO 2 (preferably in arterial blood), L-carnitine (free and total), and acylcarnitines profile in a dried blood spot [38]

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In addition, oxidative stress is characterized by the cumulative effect of more than one activity, such as a multistage process (three stages in a single cell

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Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses