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In addition to haem degradation which generates reactive oxygen species (ROS), the parasite is also thought to efflux redox active homocysteine

NE exerts its synaptic effects by binding to NE receptors after being transported back into presynaptic neurons through NE transporters (NET)

After oral GSH was administered, cognitive decline and behavioural depression in the mice was observed to decrease, results that support our plan for future human trials to test whether GSH supplements have similar affects in human counterparts

doi: 10.1007/s10565-025-10010-0 316 StockwellBRFriedmann AngeliJPBayirHBushAIConradMDixonSJet al

Increasing GSH with LC supplementation has demonstrated a positive effect on insulin sensitivity in clinical trials [63,152]