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Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs
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EV, extracellular vesicle

A thin layer of compact/dense bone borders this section, with internal cancellous/spongy bone

Automation of all processes, from generation, maintenance, immunostaining, tissue clearing and HC imaging, allows scaling and homogenization of brain organoids, as well as drug testing (Renner et al., 2020)

Although so far no licensed drug therapy for NASH exists, they can be used alone or in combination with vitamin E according to current treatment guidelines.125 153 Glitazones also have shown beneficial effects in preclinical models of cholestasis by inhibiting bile duct proliferation and fibrosis in a rat model of chronic cholestasis154 but these have clinically never been followed systematically except single case reports.155 In contrast to PPAR a direct role for PPAR in the regulation of BA metabolism has not yet been reported
