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A study by Mendes et al (77) demonstrated that ~50% of tested patients with HCU showed defective SAM activation, often linked to specific CBS mutations

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Importantly, low PA levels were significantly associated with increased odds of T2D in patients with obesity (OR = 7.61) and increased odds of diabetes with CVD in both patients with and without obesity (OR = 12.03, OR = 7.24, respectively)

Authors are also thankful to Vice-Chancellor for providing necessary facilities at Central University of Punjab, Bathinda

The authors hypothesized that bile salt hydrolase (BSH) activity of P