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Kat6a +/ mice were crossed to WT C57BL/6 mice to obtain E16.5 Kat6a +/+ and Kat6a +/ foetuses and adult mice

10.1016/j.bbabio.2015.04.009 Biochim

Studies also have showed a correlation between the intrauterine growth retardation due to hypoglycemia and to hypoxia-ischemia in the newborn with decreased plasma free carnitine concentration and impaired FAO (Xi et al., 2008)

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In particular, changes in the expression/function of OCTN2 and CT2 have been observed in human cancers indicating that cell supply of carnitine is strictly regulated during cancer development and that chemical KO of these proteins may serve as a strategy to impair energy production from FAO