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Additionally, carnitine may have neuroprotective effects and has been studied as a potential treatment for Alzheimers disease
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248 In an open-label clinical study in 30 women receiving ongoing medical therapy for fibromyalgia, eight weeks of creatine supplementation, at 3 grams daily for three weeks followed by 5 grams daily for five weeks, improved fibromyalgia severity, quality of life, sleep, disability, and pain
Promoting presynaptic inhibition allows GABAergic neurons to connect with primary afferent Ia fibers, which inhibits EAA release from Ia fibers, further preventing the nociceptive transmission to motor neurons [60]
