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Erastin inhibits the SLC7A11 subunit to block the uptake of cysteine through the system xc , which leads to GSH depletion and GPX4 inactivation, ultimately inducing ferroptosis [38]

We further demonstrate that the STAT3 pathway is involved in the enhancement of NK cell cytotoxicity by IGF-1

Cas9 may induce a troublesome off-target effect 32

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Neuronal-astrocyte metabolic association is essential for GSH synthesis, and it has been conducted on co-cultured astrocytes and neurons in which the presence of astrocytes leads to elevated GSH levels in neurons