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This selectivity represents a paradigm shift in antioxidant therapy: Hydroxyl radical specificity : Molecular hydrogen primarily neutralizes hydroxyl radicals (OH), considered the most cytotoxic reactive oxygen species with no known endogenous detoxification system, while leaving beneficial oxidative molecules intact

Neuro-immune crosstalk in CNS diseases

Hampe and Mitoma [197] speculate that region-specific differences in BBB permeability, the high concentration of neurons in the cerebellum, and the presence of autoantigens on Purkinje cells are potential explanations

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Expression of OL subtype markers was done using adenomatous polyposis coli clone CC1 (APCCC1) (mature OLs) and platelet-derived growth factor receptor (PDGFR) (immature OLs)