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Further research is needed to understand how the composition of intestinal microbiota influences the metabolic fate of ingested choline

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Current consensus holds that lymphatic endothelial cells (LECs) originate from embryonic veins ( Following LEC specification, the VEGFC-VEGFR3 axis constitutes the core growth factor signaling pathway for lymphatic development

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Its structure was controversial for several years

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As members of the dioxygenase family, they are cytosine demethylases in DNA, RNA, and histones, such as the ten-eleven translocation enzyme (TET) dioxygenase family, DNA and RNA demethylases of the AlkB homolog (ALKBH) family and Jumonji C domain-containing histone demethylases (JHDMs) ( 2+ state in the catalytic cycle of TET, thus increasing the oxidation rate of 5mC up to 8-fold in a dose- and time-dependent manner (Table 1)

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