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The major limitation of these studies is demonstrate the effect of melatonin through its receptor

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Similar inhibitory effects of zinc were found for MAPK phosphatases (MKP), which are closely related to PTPs, but largely affected the phosphorylation of threonine residues [138] and for calcineurin (CN), a threonine/serine phosphatase (IC 50 (zinc) = 10 nM10 M)

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The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

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