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Description
The TGF- response of each cell type in turn consists of multiple coordinated effects on diverse cellular functions for example, effects on collagen biosynthesis and cytokine production coupled with phenotypic activation and metabolic adaptation in fibroblasts

Howard JM, Azen C, Jacobsen DW, Green R, Carmel R

Its evidence is preclinical only (notably a 2017 study in aged mice)

and P.K.review and editing

Consistent evidence across clinical, preclinical, and in vitro studies confirms that key Clostridium taxa, predominantly CB , FP , Clostridium leptum, and Clostridium clusters IV/XIVa, are uniformly depleted in these ADs
