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As electrons are transferred along the respiratory chain complexes, small amounts of these electrons can prematurely interact with molecular oxygen, particularly at complexes I and III, leading to the formation of superoxide anion

The cultures were again treated with sorbitol to eliminate remaining schizonts

Nature genetics , 40 (10), 11601162.

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Deletion of the fibronectin gene from mouse LECs did not affect the initiation of TGF signaling at 48 hours PLI, but it blocked sustained TGF signaling at 72 hours PLI and beyond, greatly reduced injury-induced LEC proliferation, and the assembly of fibrotic ECM ( Figure 4 ) (185)