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Currently, the drugs used for the treatment of this disease are based on the administration of anti-inflammatory and immunosuppressive drugs for long periods, the disadvantage of these is that they are expensive, and have a low degree of effectiveness, with several side effects [12,13], unlike therapies based on a nutritional approach have proven to be effective for the treatment and prevention of chronic diseases, without causing side effects [5]

Frye, from The University of Arkansas for Medical Sciences

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Due to this, postmenopausal estrogen deficiency can increase the susceptibility of tissues such as bone marrow to reactive oxygen species (ROS) and inflammatory cytokines, which may contribute to increased adipogenesis and decreased osteogenesis from SSCs (286)