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They are a necessary evil since our body needs them for survival but, when in excess, they may have deleterious effects

Although the synthesis of triazole-based PROTACs follows the principles of green chemistry, these compounds have low solubilities and are challenging from a pharmaceutical industrial viewpoint due to the difficulty of scale-up

Arterioscler Thromb Vasc Biol 19 : 13161324

So, only a very small amount is able to enter the bloodstream leading to poor bioavailability and poor absorption rates

Neuroprotective effect of berberine nanoparticles against seizures in pentylenetetrazole induced kindling model of epileptogenesis: role of antioxidative, anti-inflammatory, and anti-apoptotic mechanisms