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doi: 10.1038/ncomms15965 252 ReisLMDAdamoskiDOrnitz Oliveira SouzaRRodrigues AscenoCFSousa De OliveiraKRCorra-da-SilvaFet al

For example, thioredoxins are a family of redox active proteins of approximately 12 kDa responsible for mediating numerous cytoplasmic functions influenced by available cysteine residues in the monomeric protein

This amazing antioxidant got attention when researchers revealed it might reduce melanin synthesis

Targeting metabolic vulnerabilities in specific macrophage subsets, such as limiting ferroportin-mediated iron export in M2 TAMs or enhancing ACSL4-dependent lipid peroxidation in inflammatory TAMs, may shift the TME toward a ferroptosis-permissive state

J., Rosselli-murai L