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Anecdotal reports frequently describe dramatic early responses, with multiple users noting they thought improvements were placebo on day two but by day three the changes became undeniable

This dysfunction is caused by several factors, including vagal dysfunction, impaired activity of interstitial cells of Cajal (ICC), reduced neural nitric oxide synthase activity, and increased oxidative stress[101]

Ciciola, P., Cascetta, P., Bianco, C., Formisano, L

Increased BMR & Mitochondrial Output: Enhances calorie burn and endurance potential (Kraus et al., Nature Medicine )

Exercise and intestinal permeability: another form of exercise-induced hormesis