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Huangs research focused on the design of lesion site-targeted MLT-like nanoparticles, named ConA-MelNPs, for the treatment of dry AMD

Furthermore, subsequent addition of the complex I inhibitor rotenone entirely blocked NADH oxidation and caused a potentiation in H 2 O 2 production after mitochondrial membrane potential was collapsed by addition of FCCP (95), indicating that a high NADH level is crucial for ROS production at complex I

One of the key mechanisms is the binding of metallodrugs to DNA (Jano et al., 2021)

J Immunol Res (2016) 2016:4683607

By adding L-theanine to the drinking water of cirrhotic rats established by carbon tetrachloride, it was found that L-theanine inhibited the expression of NF-B, downregulated the pro-inflammatory cytokines (e.g., IL-1 and IL-6), and profibrotic mediators (e.g., transforming growth factor and connective tissue growth factor), and promoted the expression of anti-inflammatory cytokine IL-10 and fibrinolytic enzyme metalloproteinases-13 (85)