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Chronic or acute stress can also cause the release of IL-6

The copper ion coordinates with nitrogen from the imidazole side chain of histidine, the alpha-amino group of glycine, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, forming a square-planar pyramid configuration

We here suggested that the induction of ferroptosis especially lipid peroxidation of psoriatic keratinocytes contributes to the inflammatory responses, which could be rescued by ferroptosis inhibitor Fer-1

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However, a phase IIB study in which PA101 was administered for treating IPF, conducted in 2022 showed that the difference between the two groups in improving cough was not significant [156]