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It has been reported that prolonged exposure to both UV and visible light can result in the enhanced pigmentation in all skin types, especially darker ones (Mahmoud et al., 2010)

Research by Pickart et al

Via Fenton chemistry, ferrous iron (Fe 2+ ) reacts with hydrogen peroxide to form its oxidized ferric state (Fe 3+ ), a hydroxyl anion, and a hydroxyl radical

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Also, another study suggests that IS could modify the efflux transporter P-glycoprotein (P-gp) known to be involved in the nonrenal clearance of drugs through the AhR pathway [58]