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The intramolecular disulfide bond between its two cysteine residues is believed to be important for maintaining its active conformation

[DOI] [PubMed] [Google Scholar] 28.Rickes E.L., Brink N.G., Koniuszy F.R., Wood T.R., Folkers K
The British National Formulary (BNF) provides full clinical information on hydroxocobalamin

Dr Angel Caban is Fellowship Trained in Advanced Laparoscopy and Bariatric Surgery

This happens because the body adapts to the mechanism over time, which may reduce responsiveness
