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Beyond thyroidal hyperfunction, Graves disease may manifest with extra-thyroidal complications, most notably thyroid-associated orbitopathy, in which fibroblasts and preadipocytes in the orbit express the TSHR and insulin-like growth factor 1 receptor (IGF-1R), leading to tissue expansion, edema, and fibrosis under autoantibody stimulation [19,20]

It is not approved for use in humans or animals and may not be used in food, drugs, diagnostics, or cosmetics.

Solving this dilemma and deciphering the underlying molecular mechanisms will open the way to the development of new therapies and the optimization of the diagnostic process

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So when we think about these different peptide sequences that we're utilizing they're already naturally occurring