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Introduction Reactive oxygen species (ROS) such as superoxide ( 2 O 2 ), and hydroxyl radical (OH) are highly reactive oxidant species,which are byproducts of intracellular metabolic processes, causing macromolecular damage

both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies ( Clostridium and Bifidobacterium , as observed in human associative studies (Mulak, 2021)

Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes

The effect of ketogenic diet on serum lipid concentrations in children with medication resistant epilepsy