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Molecular docking simulations and the antagonistic effect of spironolactone (SPI) in their study suggested that the Takeda G protein-coupled receptor 5 (TGR5/GPBAR1) might mediate these effects of iso-LCA on NK cells, although direct functional validation is pending (44)

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If the stress is too high SOD activity is decreased and apoptosis is activated

Tissue-engineered tracheal implants: advancements, challenges, and clinical considerations
